山中iPS細胞特別プロジェクト

山田泰広の業績一覧

【Original paper】

21.) Aoki H., Yamada Y., Hara A., Kunisada T.
Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes.
Development 136(15):2522-21, 2009 (Epub 2009 Jun 24)

20.) Aoki H., Hara A., Yamada Y., Kunisada T.
In vitro and in vivo differentiation of human embryonic stem cells into retina-like organs and comparison with that from mouse pluripotent epiblast stem cells.
Dev. Dyn (Epub Jun 19)

19.) Baba S, Yamada Y, Hatano Y, Miyazaki Y, Mori H, Shibata T, Hara A.
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus.
Cancer Sci. 100(7):1186-91. 2009

18.) Oyama T, Yamada Y, Hata K, Tomita H, Hirata A, Sheng H, Hara A, Aoki H, Kunisada T, Yamashita S, Mori H.
Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.
Carcinogenesis. 29(3):666-72. 2008

17.) Tomota H., Kuno T., Yamada Y., Oyama T., Asano N., Miyazaki Y., Baba S., Taguchi A., Hara A., Iwasaki T., Kobayashi H., Mori H.
Preventive effect of fermented brown rice and rice bran on N-methyl-N’-nitrosoguanindine-induced gastric carcinognesis in rats
Oncol Rep 19(1):11-5

16.) Miyazaki Y., Hara A., Kato K., Oyama T., Yamada Y., Mori H., Shibata T.
The effect of hypoxic microenvironment on matrix metalloproteinase expression I xenografts of human oral squamous cell carcinoma.
Int J Oncol 32(1):145-51

15.) Linhart HG, Lin H, Yamada Y, Moran E, Steine EJ, Gokhale S, Lo G, Cantu E, Ehrich M, He T, Meissner A, Jaenisch R.
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes
Dev. 21(23):3110-22. 2007

14.) Hara A., Taguchi A., Niwa M., Aoki H., Yamada Y., Ito H., Nagata K., Kunisada T., Mori H.
Localization of septin 8 in murine retina and spatiotemporal expression of septin 8 in a murine model of photoreceptoe cell degeneration.
Neurosci Lett 423(3):205-10 (Epub 2007 Aug 3)

13.) Tomita H, Yamada Y, Oyama T, Hata K, Hirose Y, Hara A, Kunisada T, Sugiyama Y, Adachi Y, Linhart H, Mori H.
Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway.
Cancer Res. 67(9):4079-87. 2007

12.) Lin H, Yamada Y, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A, Meletis K, Lo G, Jaenisch R.
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Mol Cell Biol. 26(8):2976-83. 2006

11.) Hata K, Tanaka T, Kohno H, Suzuki R, Qiang SH, Yamada Y, Oyama T, Kuno T, Hirose Y, Hara A, Mori H.
beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice.
Cancer Lett. 239(1):123-8. 2006

10.) Hochedlinger K, Yamada Y, Beard C, Jaenisch R.
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
Cell. 121(3):465-77. 2005

9.) Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout WM 3rd, Jaenisch R.
Global loss of imprinting leads to widespread tumorigenesis in adult mice.
Cancer Cell. 8(4):275-85. 2005

8.) Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H, Jaenisch R.
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.
Proc Natl Acad Sci U S A. 102(38):13580-5. 2005

7.) Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R.
Reprogramming of a melanoma genome by nuclear transplantation.
Genes Dev. 18(15):1875-85. 2004

6.) Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim M, Mintz B, Chin L, Jaenisch R.
Nuclear cloning of embryonal carcinoma cells.
Proc Natl Acad Sci U S A. 101(39):13985-90. 2004

5.) Yamada Y, Oyama T, Hirose Y, Hara A, Sugie S, Yoshida K, Yoshimi N, Mori H.
beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
Carcinogenesis. 24(1):91-7. 2003

4.) Yamada Y, Hata K, Hirose Y, Hara A, Sugie S, Kuno T, Yoshimi N, Tanaka T, Mori H.
Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.
Cancer Res. 62(22):6367-70. 2002

3.) Yamada Y, Yoshimi N, Hirose Y, Hara A, Shimizu M, Kuno T, Katayama M, Qiao Z, Mori H.
Suppression of occurrence and advancement of beta-catenin-accumulated crypts, Possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib.
Jpn J Cancer Res. 92(6):617-23. 2001

2.) Yamada Y, Yoshimi N, Hirose Y, Matsunaga K, Katayama M, Sakata K, Shimizu M, Kuno T, Mori H.
Sequential analysis of morphological and biological properties of beta-catenin-accumulated crypts. Provable premalignant lesions independent of aberrant crypt foci in rat colon carcinogenesis.
Cancer Res. 61(5):1874-8. 2001

1.) Yamada Y, Yoshimi N, Hirose Y, Kawabata K, Matsunaga K, Shimizu M, Hara A, Mori H.
Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt. Foci appearance in rat colon carcinogenesis.
Cancer Res. 60(13):3323-7. 2000

【Review】

2.) Yamada Y, Mori H.
Multistep carcinogenesis of the colon in Apc(Min/+) mouse.
Cancer Sci. 98(1):6-10. 2007

1.) Yamada Y, Mori H.
Pre-cancerous lesions for colorectal cancers in rodents: a new concept.
Carcinogenesis. 24(6):1015-9. 2003 (Epub 2003 Mar 28.)